Smile! Protein and peptide sample preparation automated

Dedicated instrumentation to improve sample throughput for LC-MS analysis - compatible with all the iST workflows

The challenge:

How do you bring further standardization, reproducibility and hands on time savings to proteomics sample preparation for LC-MS analysis when you have already successfully addressed the many challenges of time, sample contamination, sample loss and reproducibility?

The solution:

Automate! Introducing the PreON platform; built to address the demands of reproducible, robust and sensitive proteomics sample preparation for LC-MS analysis. It allows research labs to automate proteomics processing at the push of a button decreasing the hands-on time from 1 hour (iST, iST-NHS and iST-BCT sample preparation) to about 5 minutes!

Apply! Simple, streamline workflows

1. Samples

Samples should be liquid, homogenates or a soft pellet.

2. Lyse, reduce, alkylate

Add LYSE reagent, incubate for 10 mins at 95°C.

3. Digest and label

Cool, add DIGEST reagent, incubate for 60 mins at 37°C. Label according to vendor instructions.

4. Purify

Load onto cartridge, WASH and ELUTE. Dry and resuspend in LOAD.

5. MS analysis

Inject and analyse to see improved peptide identities.

Results

The PreON eliminates manual processing errors and pipetting variability, improving quality and reproducibility. Spend less time preparing your samples, increase throughput and achieve better results.

The PreON significantly reduces variability in chemically-labeled proteomics sample preparation by reducing manual steps and eliminating processing errors. Spend less time preparing your samples while achieving better results.

PreOmics'

PreON

values

Smile

Improved sample quality

High reproducibility: R²>0.9
Working range: 1-100 µg
Increased peptide and protein identifications
Can prepare up to 12 unlabeled sample or 16* labeled samples
Benchtop footprint (0.81 x 0.65 x 0.62 m HxWxD, weight 71.5kg)
Installation and training included

* with sample pooling before clean-up step

Relax

Sample preparation fully automated

True walk-away automation for label-free and chemical labeling workflows
Eliminates manual processing steps (only 5 mins hands on time)
Works seamlessly with pre-loaded PreOmics protocols
PreON is installed and running samples in less than a day
Intuitive touch screen menus
Overnight evaporation option
Range of service plans available

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‍

Realize

Cleaner peptides ready for analysis

Dual clean-up step removes hydrophilic and hydrophobic contaminants
Achieve ready to measure peptides
Reduce mass spectrometry downtime
Optical and ultrasonic detectors for accurate labware and liquid detection
Integrated centrifuge (12 position)
Onboard heater shaker (10 – 2,000 rpm; up to 83°C)
Optional pauses to help maintain TMT efficiency and conserve TMT reagents
CE and CSA compliant

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Automation for the next generation

PreON

PreON

Instrument

Instrument

Dedicated instrumentation to improve sample throughput for LC-MS analysis - compatible with all the iST workflows

PreON

Instrument

Instrument

Dedicated instrumentation to improve sample throughput for LC-MS analysis - compatible with all the iST workflows

iST PreON Tips

P.O.00091

1024 tips

$107

101 €

Pre-racked, 1024 pcs., 200 µL

iST PreON 8x

P.O.00077

8 sample kit

$403

374 €

With PreON plasticware included

iST PreON 96x

P.O.00079

96 sample kit

$3,266

2.724 €

With PreON plasticware included

iST-NHS PreON 12x

P.O.00078

12 sample kit

$610

552 €

With PreON plasticware included

iST-NHS PreON 96x

P.O.00080

96 sample kit

$3,266

2.724 €

With PreON plasticware included

iST-BCT PreON 8x

P.O.00130

8 sample kit

$468

443 €

With PreON plasticware included

iST-BCT PreON 96x

P.O.00131

96 sample kit

$3,905

3.454 €

With PreON plasticware included

The products displayed are for visual representation only and may differ from those received

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Imagine

Applying the science

Find out more about the wide range of applications and sample types to which PreOmics technology has been successfully applied

Visit Technology Page

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