Smile! Redefining proteomics depth for human plasma samples

Obtaining meaningful detection of low-abundance proteins in blood plasma remains a key obstacle in proteomic research. The wide dynamic range of protein concentrations and the complex, heterogeneous nature of plasma limit LC-MS–based analyses, preventing comprehensive characterization of the plasma proteome. As a result, data often lack robustness and reproducibility, with high-abundance proteins masking low-abundant targets. Traditional workflows are complex, time-consuming, and difficult to automate, offering limited flexibility and scalability for large sample cohorts.

The integration of Biognosys’ P2 single particle technology with PreOmics’ proven iST workflow introduces a next-generation, particle-based enrichment solution that improves access to low-abundance proteins in human EDTA plasma. The P2–iST Plasma workflow provides high-quality, LC-MS–ready peptides in just a few hours with exceptional reproducibility, analytical depth, and confidence. Combining precision, flexibility, and scalability, this optimized workflow empowers researchers to achieve consistent, high-quality results even from the most challenging plasma samples.