"At the Helsinki Proteomics Center, we have benchmarked essentially all major plasma depletion/enrichment strategies on the market. When depth matters, P2-iST consistently comes out on top. For us it has been a game changer – it puts robust, deep plasma proteomics into the hands of any lab without expensive proprietary hardware. The reproducibility and depth we see with P2-iST on our Orbitrap Astral platform makes it ideal for medium scale clinical and translational plasma studies."