Reproducible and reliable cell lysis and tissue homogenization needs to produce a smooth and easy to pipette homogenate and minimize the possibility of cross-contamination. A specific consideration for proteomics is the release of the maximum number of proteins to make them accessible for the next steps of sample preparation. Additionally, lab space, the requirement for chiller units, and the noise made by some processes can also impact instrument choice.

The BeatBox is a fast and easy to use instrument for up to 96 samples, which completes the homogenization in as little as 10 minutes without sample cross contamination and minimal heat induction. The BeatBox has a surprisingly small footprint and quiet operation in comparison to traditional tissue processing machines. With the BeatBox, cell lysis and tissue homogenization can be integrated into the PreOmics iST sample preparation workflows.