Applications/Bioanalysis and targeted analysis

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Research and Discovery
Bioanalysis and targeted analysis

Bioanalysis and targeted analysis

In targeted mass spectrometry-based protein quantification, information about the peptide or protein is already known, typical experiments include:
 ·      Protein dynamics e.g. steady-state concentration, turn-over rates (PK, PD studies)
·      Absolute quantitation e.g. biomarker measurement or dosed biological drugs
·      Relative quantitation
Consideration of appropriate internal standards in needed, stable-isotope labeled proteins should be added before the digestion step and stable-isotope labeled peptides can be spiked-into our iST, iST-NHS and iST-BCT workflows after the digestion step. Additionally surrogate matrices maybe needed for calibration and quality control samples. Dedicated resources are shown below and our technical support team would be happy to help with advice.

PreOmics Values


Improved sample quality

High reproducibility: R
Working range: 1-100 µg
Increased peptide and protein identifications


Quicker methodology

Less than 2.5 hours hands-on time
Single step incorporating lysis, reduction and alkylation
All-in-one solution, all reagents provided
Compatible with standard lab equipment


Cleaner peptides ready for analysis

Dual clean up step removes hydrophilic and hydrophobic contaminants
Achieve ready-to-measure peptides
Reduce mass spectrometry downtime
Manual to fully automated processing options available


Applying the science
Find out more about the wide range of applications and sample
types to which PreOmics technology has been successfully applied